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THERE IS CURRENTLY NO EVIDENCE THAT THE USE OF “NATURAL” ESTROGENS RESULTS IN A DIFFERENT ENDOMETRIAL RISK PROFILE THAN SYNTHETIC ESTROGENS OF EQUIVALENT ESTROGEN DOSE.ĮSTROGENS WITH AND WITHOUT PROGESTINS SHOULD NOT BE USED FOR THE PREVENTION OF CARDIOVASCULAR DISEASE OR DEMENTIA. ADEQUATE DIAGNOSTIC MEASURES, INCLUDING ENDOMETRIAL SAMPLING WHEN INDICATED, SHOULD BE UNDERTAKEN TO RULE OUT MALIGNANCY IN ALL CASES OF UNDIAGNOSED PERSISTENT OR RECURRING ABNORMAL VAGINAL BLEEDING. WARNING: ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER.ĬLOSE CLINICAL SURVEILLANCE OF ALL WOMEN TAKING ESTROGENS IS IMPORTANT. Ask your doctor or pharmacist for more information. This is not a complete list of Depo-Estradiol drug interactions. Verapamil (Calan, Covera, Isoptin, Verelan).Rifampin (Rifadin, Rimactane, in Rifamate).Phenytoin (Dilantin, Phenytek) rifabutin (Mycobutin).Other medications that contain estrogen.Medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), delaviridine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra),nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase).Griseofulvin (Fulvicin, Grifulvin, Gris-PEG).Diltiazem (Cardizem, Dilacor, Tiazac, others).Carbamazepine (Carbatrol, Epitol, Tegretol).Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral).Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.